So, it takes up more and more memory until your hard drive is full (opens new window) and there is no room for the swap files, the system will report that it has run out of application memory. When running an app on Mac, if all physical RAM are used, macOS will create swap files, which takes up disk space. Your boot disk has little free space for running apps. It’s a common practice to run several apps at the same time however, accumulation of excessive apps in the background takes up more and more space and finally leads to the problem of “system has run out of application memory”.Ģ. Four possible reasons account for the problem.ġ. When your Mac says system has run out of application memory, it means that your computer doesn't have enough memory required by applications to run. What Does System Has Run Out of Application Memory Mean?